VAOTV-1: Novel Orthototivirus-Like Virus in Vulvovaginal Candidiasis Patients

A study identified a novel double-stranded RNA virus, Vaginal-associated orthototivirus-like 1 (VAOTV-1), in vaginal swab samples from patients with vulvovaginal candidiasis. The dataset includes a partial genome sequence of 4,332 bp, encoding a complete RNA-dependent RNA polymerase and a partial capsid protein. It was authored by Ziyuan Dai and last updated on March 19, 2026.

Use Cases

• Phylogenetic analysis based on the RNA-dependent RNA polymerase (RdRp) and capsid protein sequences.
• Comparative genomics to assess divergence from known Totiviridae members based on the reported 47.43% amino acid identity.
• Characterization of novel viral lineages in human-associated environments based on the described partial genome and protein annotations.

Strengths

• Includes a specific, novel viral genome sequence of 4,332 base pairs.
• Provides detailed protein annotations for a complete RdRp (729 amino acids) and a partial capsid protein (532 amino acids).
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (11.9 KB), indicating limited scope.

Provenance

Source

figshare, author Ziyuan Dai.

Collection Method

Viral metagenomic sequencing of vaginal swab samples using an Illumina NovaSeq platform, followed by assembly and annotation.

Freshness

Last updated 2026-03-19 06:49:50; freshness should be verified.