Liver-Heart Metabolic Axis Phenotypes in Type 2 Diabetes

41 individuals with controlled type 2 diabetes underwent PET/CT scans and hyperinsulinemic clamp tests. The study by Queralt Martín-Saladich identified three distinct metabolic phenotypes linked to risks of liver disease and cardiovascular disease. Data was uploaded to figshare in March 2026.

Use Cases

• Identify high-risk metabolic phenotypes based on liver and heart glucose uptake patterns.
• Correlate tissue-specific insulin sensitivity with biomarkers of liver fat and coronary calcifications.
• Validate PET-derived glucose uptake measures against systemic insulin resistance metrics.
• Develop personalized risk profiles for type 2 diabetes complications.
• Explore the liver-heart axis as a target for monitoring and treatment strategies.

Strengths

• Data includes PET/CT imaging results from 41 individuals.
• Study derived tissue-specific insulin-mediated glucose uptake from imaging.
• Identified three distinct phenotypes with clinical risk implications.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset size is 15.7 KB, indicating a very limited scope.

Provenance

Source

figshare

Collection Method

Cross-sectional study involving biochemical tests and [18F]FDG PET/CT scans before and after a hyperinsulinemic euglycemic clamp.

Freshness

Last updated 2026-03-19 05:17:37; freshness should be verified.