Genetic Analysis of Age-Specific Vitiligo Subtypes from Post-GWAS Analysis

A figshare-hosted dataset by Qingqing Si, last updated in May 2026, presents results from an integrative Post-GWAS analysis of vitiligo. The 29.8 MB Excel file contains findings on the genetic architecture differences between early-onset and late-onset vitiligo subtypes, including genetic correlation, cell-type enrichment, and identified core target genes.

Use Cases

• Identifying subtype-specific genetic risk genes based on the 46 EO-associated and 56 LO-associated genes mentioned.
• Analyzing cell-type-specific heritability enrichment patterns in immune cell populations described in the results.
• Investigating tissue microenvironment contexts using the spatial mapping results for EO and LO genes.
• Validating core target genes like RNASET2, GZMB, and TEF for potential diagnostic or therapeutic applications.

Strengths

• Dataset is licensed under CC-BY-4.0, allowing for open sharing and adaptation.
• Analysis integrates multiple methods (LDSC, SMR, colocalization) for a multi-layered genetic investigation.
• Includes exploratory clinical validation results from patient blood samples (qRT-PCR and ELISA).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The dataset's freshness, last updated 2026-05-08, should be verified for current research relevance.

Provenance

Source

figshare

Collection Method

Integrative Post-GWAS analysis employing linkage disequilibrium score regression, stratified LDSC, multi-marker analysis of genomic annotation, and summary-data-based Mendelian randomization.

Time Range

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Freshness

Last updated 2026-05-08 05:48:13

Geography

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