Rat Sepsis Study: Gut Microbiota and Early Gut-Liver Injury in CLP Model

Table 1_Dissociation between gut microbiota remodeling and early gut-liver injury in CLP-induced sepsis is a dataset from a preclinical sepsis study. The research, authored by Tijana Mašić and shared on figshare, investigates the relationship between gut microbiota changes and early organ injury in a rat model of severe polymicrobial sepsis. Data likely includes outcomes assessed within the first 24 hours and survival monitored for 7 days.

Use Cases

• Analyzing the association between gut microbiota restructuring and early hepatic oxidative stress based on the study's described outcomes
• Modeling the impact of metabolic preconditioning on sepsis survival based on the described pretreatment and mortality results
• Investigating temporal patterns of organ injury and inflammatory activation in early sepsis based on the 24-hour assessment window

Strengths

• Data is derived from a controlled experimental study with a defined protocol (4-week pretreatment followed by CLP induction)
• Includes temporal analysis with assessments at multiple time points (within 24 hours and 7-day survival monitoring)
• Released under a permissive CC-BY-4.0 license for reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Dataset scope is limited to a specific rat model (Sprague-Dawley, CLP-induced sepsis) and may not generalize directly

Provenance

Source

figshare

Collection Method

Experimental data from a preclinical study involving cecal ligation and perforation (CLP) in rats.

Time Range

Outcomes assessed within the first 24 hours post-sepsis induction, with survival monitored for 7 days.

Freshness

Last updated 2026-04-20 05:22:25; freshness should be verified

Geography

Laboratory study; geographic location of the research institution is unknown.