Prognostic Value of Liver Enzyme Ratio in 1,069 Brain Injury Patients

A retrospective cohort study of 1,069 patients with traumatic brain injury, intracerebral hemorrhage, or aneurysmal subarachnoid hemorrhage, authored by Dilmurat Gheyret and last updated in June 2026. It examines the disease-specific prognostic value of the aspartate-to-alanine aminotransferase ratio (AAR) for predicting unfavorable neurological outcomes at discharge. The dataset likely contains patient-level clinical and outcome data from a single-center study.

Use Cases

• Training a binary classifier to predict unfavorable neurological outcomes based on liver enzyme ratios and injury type.
• Investigating effect modification and heterogeneity in biomarker performance across different neurosurgical conditions.
• Validating the hypothesis of distinct liver-brain interaction mechanisms in traumatic versus hemorrhagic brain injury.

Strengths

• Includes data from 1,069 patients across three distinct brain injury types.
• Provides specific statistical results, such as an adjusted odds ratio of 2.15 for AAR in traumatic brain injury.
• Uses multivariable logistic regression and formal interaction testing, suggesting a rigorous analytical approach.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect single-center bias inherent to the source platform.

Provenance

Source

figshare

Collection Method

Retrospective cohort study of consecutive patients.

Freshness

Last updated 2026-06-04 04:27:43; freshness should be verified.