Meta-Analysis of Astragalus mongholicus Bunge for Wound Healing in Animal Models

A systematic review and meta-analysis of 21 preclinical animal studies involving 559 animals, evaluating the efficacy and safety of the botanical drug Astragalus mongholicus Bunge for wound healing. The analysis, registered in PROSPERO (CRD420250641262), was conducted by Jun Zhang and published on figshare in 2026. The document reports pooled effect sizes for wound contraction, angiogenesis, collagen deposition, and inflammation.

Use Cases

• Assessing the pooled therapeutic effect of Astragalus mongholicus Bunge based on reported standardized mean differences for wound contraction.
• Evaluating evidence for secondary outcomes like angiogenesis and collagen deposition mentioned in the results.
• Informing the design of future preclinical or clinical trials based on the systematic review's conclusions and identified knowledge gaps.

Strengths

• Includes data from 21 studies with 559 animals, providing a quantitative synthesis.
• Reports specific pooled effect metrics, such as a standardized mean difference of 4.18 for wound contraction.
• Follows a registered protocol (PROSPERO CRD420250641262) and uses SYRCLE risk-of-bias assessment.

Limitations

• The dataset is a 32.8 KB DOCX file containing a review article, not the underlying raw study data.
• Row and column counts for any underlying data are unknown, limiting suitability assessment for direct computational analysis.
• The description provides results but no column-level documentation for any potential supplementary data.

Provenance

Source

figshare

Collection Method

Systematic search of seven databases for randomized controlled animal studies.

Freshness

Last updated 2026-04-17 05:08:55.