Table 1_Dose-dependent protective effects of Tripterygium wilfordii glycosides on joint an

Shangwen Qi published experimental data on figshare in 2026. The dataset contains results from a study on collagen-induced arthritis rats treated with Tripterygium wilfordii glycosides (TWG). It includes histopathological scores, cytokine expression levels, and gut microbiota sequencing results across multiple dose groups and a prednisolone control.

Use Cases

• Analyze dose-response relationships for drug efficacy based on arthritis severity and lung injury scores.
• Investigate correlations between gut microbiota composition (e.g., Lactobacillus, Desulfovibrio) and inflammatory markers (IL-6, TNF-α).
• Predict microbial functional pathways (e.g., short-chain fatty acid production) using PICRUSt2 inference results.
• Compare the anti-inflammatory and anti-fibrotic effects of a herbal treatment (TWG) against a standard steroid (prednisolone).

Strengths

• Data includes results from six distinct experimental groups (normal control, model, three dose groups, prednisolone control).
• Multiple data modalities are described: histopathology scores, RT-qPCR for cytokines, Western blot for proteins, and 16S rRNA sequencing.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (20.6 KB), indicating it likely contains summary results rather than raw sequencing or image data.

Provenance

Source

Shangwen Qi via figshare.

Collection Method

Experimental data from a controlled animal study using collagen-induced arthritis (CIA) in Wistar rats.

Time Range

The experiment was conducted over 43 days, with treatments administered from day 15 to day 42.

Freshness

Last updated 2026-04-23 05:27:26; freshness should be verified.