DOT1L Epigenetic Regulation of Immune Checkpoints in Lung Adenocarcinoma

Tabular data from a study linking the histone methyltransferase DOT1L to immune evasion in lung adenocarcinoma. The dataset likely contains gene expression and epigenetic markers related to immune checkpoints like PD-L1, LAG3, and CD276, derived from analyses of TCGA data, single-cell RNA-seq, and clinical specimens. It was published by Xiwu Rao on figshare under a CC-BY-4.0 license and last updated on March 18, 2026.

Use Cases

• Correlating DOT1L expression with patient prognosis based on TCGA data mentioned in the description
• Analyzing epigenetic activation of immune checkpoint genes like PD-L1 and LAG3
• Modeling the relationship between H3K79me2 enrichment and JAK1/STAT3 pathway activity
• Investigating the impact of pharmacological DOT1L inhibition (SGC0946) on immune cell subsets

Strengths

• Data is derived from multiple sources including TCGA and single-cell RNA-seq, as stated in the description
• Includes findings validated with clinical LUAD specimens
• File size is 34.5 KB, making it quick to download and inspect

Limitations

• Row count and specific column definitions are unknown
• Column-level documentation is absent; field semantics must be inferred after download
• The 34.5 KB size suggests a very limited scope, likely summary statistics rather than raw experimental data

Provenance

Source

figshare, author Xiwu Rao

Collection Method

Integrative analysis of TCGA data, single-cell RNA-seq, ChIP-seq, and clinical specimen validation, as described

Freshness

Last updated 2026-03-18 07:38:03