Meta-Analysis of Drug-Coated Balloons vs. Drug-Eluting Stents for Coronary Artery Disease

A systematic review and meta-analysis of 23 randomized controlled trials comprising 8,123 patients, comparing drug-coated balloons (DCB) and drug-eluting stents (DES) for coronary artery disease. The analysis, conducted by Yuting Wang and last updated in May 2026, includes lesion-specific and presentation-specific outcomes. It synthesizes data from PubMed, Embase, CENTRAL, and Web of Science from inception to March 2026.

Use Cases

• Comparing the efficacy of DCB vs. DES based on outcomes like target lesion revascularization (TLR) and major adverse cardiac events (MACE).
• Analyzing lesion-specific treatment effects for de novo lesions versus in-stent restenosis (ISR).
• Investigating the safety profile of different DCB types (paclitaxel vs. sirolimus) based on cardiac death signals.
• Assessing treatment outcomes in specific patient subgroups, such as those with small vessel disease or different clinical presentations (STEMI/NSTEMI).

Strengths

• Includes data from 23 randomized controlled trials, a standard for clinical evidence.
• Analyzes 8,123 patients, providing a substantial sample for meta-analysis.
• Conducts detailed subgroup analyses by lesion type, vessel size, clinical presentation, and DCB type.
• Reports specific odds ratios and confidence intervals for key clinical endpoints.

Limitations

• The dataset is a 22.7 KB document (DOCX), indicating it contains summary results, not the underlying patient-level trial data.
• Column-level documentation is absent; field semantics must be inferred from the manuscript.
• Some findings, such as those for sirolimus-coated balloons, are noted as exploratory and based on limited events.

Provenance

Source

Yuting Wang via figshare.

Collection Method

Systematic review and meta-analysis of randomized controlled trials from PubMed, Embase, CENTRAL, and Web of Science.

Time Range

Trials from database inception to March 2026.

Freshness

Last updated 2026-05-18 05:53:52.