Ethyl Ferulate Effects on E. Coli Biofilm and Antibiotic Synergy

Experimental results detail the dual antibacterial action of ethyl ferulate against Escherichia coli. Data includes measurements of biofilm inhibition, exopolysaccharide production, bacterial motility, and gene expression changes for csgD, pdeR, dgcM, fliC, fliM, and motB. The dataset was authored by Zhijin Zhang and uploaded to figshare in April 2026.

Use Cases

• Analyze correlations between ethyl ferulate concentration and biofilm inhibition levels measured by crystal violet staining.
• Model gene expression changes (e.g., csgD, fliC) as predictors for reduced exopolysaccharide production.
• Predict synergistic antibiotic efficacy (e.g., with fosfomycin, gentamicin) based on combined treatment data with ethyl ferulate.
• Classify bacterial motility outcomes using expression levels of flagella-related genes fliM and motB.

Strengths

• Data covers multiple experimental assays: crystal violet staining, Alamar Blue assay, and qRT-PCR gene expression analysis.
• Results include quantified effects on five commercially available antibiotics (fosfomycin sodium, cefquinome, gentamicin, tetracycline, azithromycin).

Limitations

• Dataset is very small at 16.2 KB, containing summary results rather than raw experimental observations.
• No sample data or column definitions are provided, limiting direct computational analysis.
• The study focuses on a single bacterial strain (E. coli), limiting generalizability.

Provenance

Source

figshare

Collection Method

Laboratory experiments using crystal violet staining, Alamar Blue assay, and quantitative reverse transcription polymerase chain reaction (qRT-PCR).

Time Range

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Freshness

Last updated in April 2026.

Geography

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