Dynamic Chemokine Profiles in Cervical Mucus During Healthy Pregnancy

133 cervical mucus samples from pregnant women were analyzed across three gestational periods for pH and 14 cytokines. IP-10 and MIP-1β levels were approximately double in early pregnancy compared to late pregnancy, showing significant positive correlations with pH. The dataset, authored by Ho Yen Chueh and last updated in 2026, provides non-invasive candidate markers for gestational immune adaptation.

Use Cases

• Modeling gestational immune adaptation based on dynamic chemokine profiles.
• Correlating cervical mucus pH with cytokine levels to understand the cervicovaginal microenvironment.
• Identifying potential non-invasive biomarkers for adverse pregnancy outcomes based on IP-10 and MIP-1β levels.

Strengths

• Includes data from 133 pregnant women, providing a substantive cohort.
• Measures 14 cytokines and growth factors per sample, offering a multi-analyte profile.
• Samples were collected across three gestational periods, enabling longitudinal analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 21.4 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Prospective cohort study analyzing cervical mucus samples using colorimetric pH strips and multiplex immunoassay.

Freshness

Last updated 2026-05-15 05:27:45; freshness should be verified.