Sjögren's Disease Murine Model: Lacrimal Gland ELS Progression

Sara Abdelhamid's research data investigates ectopic lymphoid structure formation in lacrimal glands of a Sjögren's disease mouse model. The dataset likely contains gene expression and histological characterization data from the male NOR mouse strain across early to advanced disease stages. It was last updated on March 19, 2026.

Use Cases

• Analyze gene expression patterns for ELS formation markers (Ltb, Glycam1, Cxcl13) based on the description
• Model the time course of lymphocytic infiltration and glandular apoptosis based on the described stages
• Correlate histological features (B/T cell zones, germinal centers) with disease severity indicators
• Investigate mechanisms of glandular apoptosis and ferroptosis based on Fasl and Gpx4 expression data

Strengths

• Data is licensed under CC-BY-4.0, facilitating open reuse
• Focus on a specific murine model (male NOR mouse) provides a controlled experimental context
• Description details specific gene targets and histological markers for analysis

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The 5.9 MB file size suggests a relatively small dataset

Provenance

Source

figshare

Collection Method

Data from a laboratory study characterizing lacrimal glands via histology, immunofluorescence, and gene expression analysis.

Freshness

Last updated 2026-03-19 06:48:56; freshness should be verified