TCR Repertoire Dynamics in Advanced NSCLC Patients Undergoing First-Line Chemotherapy

A clinical study dataset tracking peripheral T-cell receptor beta (TCRβ) repertoire dynamics in patients with recurrent locally advanced or stage IV non-small cell lung cancer (NSCLC) without actionable mutations. The data includes measurements from 42 enrolled patients, with blood samples collected at baseline, chemotherapy completion, and disease progression between 2021 and 2024 at Ramathibodi Hospital. Metrics such as Shannon diversity, Pielou evenness, TCR convergence frequency, and unique clone counts were analyzed to explore associations with disease control and overall survival.

Use Cases

• Modeling the relationship between TCR repertoire convergence and disease control based on the reported convergence frequency differences.
• Predicting patient survival based on longitudinal changes in unique clone counts and Shannon diversity metrics.
• Clustering patient immune response profiles using principal component analysis (PCA) of clonal frequencies to distinguish disease control from progressive disease.
• Investigating chemotherapy-induced immune attrition by analyzing repertoire changes at baseline, treatment completion, and progression time points.

Strengths

• Prospective study design with blood samples collected at three specific clinical time points (T1, T2, T3).
• Includes analysis of multiple immune repertoire metrics: Shannon diversity, Pielou evenness, TCR convergence frequency, and unique clone counts.
• Data is associated with clinical outcomes, including disease control status and overall survival, for 34 baseline-evaluable patients.
• Sequencing was performed with a standardized platform (Ion Torrent Oncomine TCR Beta-LR) and samples were rarefied to over 1.5 million reads.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (21.5 KB), indicating it likely contains summary or processed results rather than raw sequencing data.
• Significant longitudinal attrition was noted, with only 15 patients evaluable at the second time point, potentially limiting statistical power.

Provenance

Source

Narumol Trachu, Ramathibodi Hospital.

Collection Method

Prospective clinical study with peripheral blood collection and TCRβ sequencing.

Time Range

2021–2024.

Freshness

Last updated 2026-04-13 04:35:41; freshness should be verified.

Geography

Data collection occurred at Ramathibodi Hospital; specific country is not stated.