Acute Chikungunya Fever Immune Profiles from Guangdong Cohort

34 patients with acute chikungunya fever and 20 healthy controls were studied in Guangdong, China during a 2025 outbreak. The dataset contains flow cytometry and cytokine analysis results, authored by Mingya Xiao and published in 2026. It measures T cell subsets and inflammatory cytokine levels.

Use Cases

• Analyze correlations between CD3+ T cell counts and clinical symptom severity like arthralgia.
• Model the association between pro-inflammatory cytokines IL-1β, IL-6, IL-8 and neutrophil counts or systemic inflammatory markers.
• Investigate demographic risk factors by comparing immune dysregulation metrics like NKT cell depletion across age, gender, and comorbidity status.
• Identify potential biomarkers for disease severity by linking T cell subset alterations with cytokine profile elevations.

Strengths

• Prospective cohort design with 34 patient cases and 20 control subjects.
• Multiplex cytokine analysis and flow cytometry provide quantified immune cell and protein measurements.

Limitations

• Small sample size of 54 total participants limits statistical power for subgroup analysis.
• Single geographic region (Guangdong Province) and single outbreak timeframe may limit generalizability.
• Data is presented in a DOCX document (307.3 KB), requiring extraction for computational analysis.

Provenance

Source

figshare, authored by Mingya Xiao.

Collection Method

Prospective cohort study using flow cytometry and multiplex cytokine analysis.

Time Range

2025 outbreak period.

Freshness

Data reflects a 2025 outbreak and was last updated in April 2026.

Geography

Guangdong Province, China.