Early Proteomic Signatures of Alzheimer's Disease in 3xTg-AD Mouse Retina and Brain

Artjola Puja's proteomic dataset compares retinal and brain tissue from 4-week-old triple-transgenic Alzheimer's disease (3xTg-AD) mice. It contains quantitative profiles of 92 significantly altered proteins in the retina and 130 in the brain, with eight overlapping proteins. The data was uploaded to figshare on 2026-05-18.

Use Cases

• Identify early common proteomic changes in Alzheimer's disease based on the eight overlapping proteins between retina and brain.
• Analyze tissue-specific mitochondrial dysfunction based on described alterations in mitochondrial energetics and respiratory chain components.
• Investigate early changes in vision-related pathways based on the reported reduction of vision-related proteins in the retinal proteome.
• Study preclinical alterations in protein homeostasis and vesicular transport based on the five overlapping proteins involved in these processes.

Strengths

• Proteomic profiles are from a specific, early disease stage (4-week-old mice prior to detectable retinal abnormalities).
• Dataset quantifies a specific number of altered proteins (92 in retina, 130 in brain).
• Data is openly available under a CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• Data is from a specific mouse model (3xTg-AD); applicability to human Alzheimer's disease may be limited.
• The dataset is small (126.8 KB), indicating limited scope.

Provenance

Source

figshare, author Artjola Puja.

Collection Method

Quantitative proteomic profiling of retina and brain tissue from 4-week-old 3xTg-AD mice.

Time Range

Data reflects a single time point from 4-week-old mice.

Freshness

Last updated 2026-05-18 05:36:33; freshness should be verified.

Geography

Laboratory mouse model; geographic origin is not specified.