Early vs. Late Parenteral Nutrition and Fistula Risk in High-Risk Open Abdomen Patients

A retrospective cohort study of 284 high-risk open abdomen patients with acute gastrointestinal injury and persistent enteral nutrition intolerance, conducted at a single center between January 2019 and December 2024. The data compares outcomes for 102 propensity score-matched patient pairs, analyzing the association between early supplemental parenteral nutrition initiation and the subsequent incidence of enteroatmospheric fistula. The dataset was authored by Wenyue Wang and last updated in May 2026.

Use Cases

• Analyze the association between timing of supplemental nutrition and fistula risk based on the landmark analysis at ICU Day 7.
• Compare secondary clinical outcomes, such as mechanical ventilation duration, between treatment groups.
• Validate propensity score matching methods in a single-center, high-risk patient cohort.
• Study the relationship between early energy-protein delivery and complications in patients with persistent enteral intolerance.

Strengths

• Includes data from 284 screened patients with 102 propensity score-matched pairs, providing a basis for comparative analysis.
• Reports specific statistical results, including a relative risk of 0.42 (95% CI, 0.23–0.75) for the primary outcome.
• Covers a defined time period from January 2019 to December 2024.
• Uses a clear landmark analysis methodology with groups defined by SPN initiation before or after ICU Day 7.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying analytical dataset is unknown, which may limit suitability assessment.
• Data is from a single-center study, which may limit generalizability.

Provenance

Source

Wenyue Wang via figshare.

Collection Method

Single-center retrospective cohort study.

Time Range

January 2019 to December 2024.

Freshness

Last updated 2026-05-22 06:03:23; freshness should be verified.