Antimicrobial Stewardship Outcomes in Hospitalized COVID-19 Patients

Encompassing results from a quasi-experimental study of 1,289 hospitalized COVID-19 patients, comparing outcomes before and after implementing an antimicrobial stewardship program. It reports significant reductions in days of therapy per 1,000 patient-days and rates of inappropriate antibiotic use for specific infection types. The study was conducted by Ariana Martínez-Suárez.

Use Cases

• Analyze the reduction in 'days of therapy (DOT)/1,000 patient-days' between pre-ASP and ASP cohorts to quantify program impact.
• Compare 'rate of antibiotic use for suspected pneumonic coinfections' and 'inappropriate antibiotic use rate' across cohorts to evaluate intervention effectiveness.
• Model the relationship between '30-day mortality' and '30-day readmission rates' with the implementation of the stewardship program.
• Examine the 'acceptance rate' of recommendations, such as 'discontinuing antibiotics' and 'adjusting the antibiotic regimen', made by the stewardship team.

Strengths

• Study includes 1,289 patient records split between pre-intervention (561) and post-intervention (728) cohorts.
• Reports specific, statistically significant outcome metrics like a reduction in DOT/1,000 patient-days from 162.96 to 105.71.
• Examines multiple secondary outcomes including rates of inappropriate use, Clostridioides difficile infection, mortality, and readmissions.

Limitations

• Dataset is small in file size (688.8 KB), suggesting limited raw data or a summary document rather than a full patient-level dataset.
• No column-level schema or sample data is provided, limiting direct analytical use.
• Findings are from a single quasi-experimental study, which may limit generalizability.

Provenance

Source

figshare

Collection Method

Quasi-experimental before-and-after study comparing retrospective pre-ASP and prospective ASP cohorts.

Time Range

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Freshness

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Geography

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