Meta-Analysis of Photobiomodulation for Breast Cancer Lymphedema
by Chenjie Qian·Updated 2mo ago
19.3 KB1files
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Description
Chenjie Qian's systematic review and meta-analysis synthesizes data from 9 randomized controlled trials involving 312 participants with breast cancer-related lymphedema. The analysis quantifies the effects of photobiomodulation therapy on limb volume, circumference, grip strength, and pain. The review was registered in PROSPERO and followed PRISMA guidelines, with evidence assessed using RoB 2, PEDro, and GRADE frameworks.
Use Cases
Analyze pooled effect sizes for limb volume reduction (SMD = -0.78) and circumference (MD = -3.61 cm) from the meta-analysis results.
Assess the relationship between photobiomodulation therapy and functional outcomes like grip strength (MD = 1.72 kg) and pain intensity (MD = -0.29).
Evaluate the methodological quality and risk of bias across the 9 included RCTs using the reported RoB 2 and PEDro scale assessments.
Examine the heterogeneity of treatment effects as indicated by the reported I² statistics for volume (22%), circumference (44%), and grip strength (14%).
Strengths
Analysis is based on 9 randomized controlled trials, a standard for clinical evidence synthesis.
Quantitative synthesis includes 312 total participants with breast cancer-related lymphedema.
Reports specific pooled effect measures (e.g., SMD, MD) with 95% confidence intervals for key outcomes like limb volume and pain.
Limitations
Limited to a small total sample size of 312 participants across all studies.
Evidence certainty is rated as moderate by GRADE, with safety conclusions limited by sparse adverse-event reporting.
The dataset is a 19.3 KB document containing summary meta-analysis results, not the underlying patient-level trial data.
Provenance
Source
Chenjie Qian via figshare.
Collection Method
Systematic review and meta-analysis of RCTs from PubMed, CENTRAL, and Embase databases.
Time Range
Literature search covered studies up to January 20, 2026.
Freshness
Literature search was conducted up to January 20, 2026, and the record was last updated on 2026-03-23.
Data is presented as a summary within a 19.3 KB DOCX file; raw trial data or a structured dataset is not provided. Use is governed by a CC BY 4.0 license.