Meta-Analysis of Physical Activity Effects on Health Outcomes in Sjögren's Syndrome

Six randomized controlled trials involving 277 participants with Sjögren's syndrome form the basis of this systematic review. The document, authored by Qianfei Gao and uploaded in April 2026, analyzes the standardized mean differences for outcomes like cardiopulmonary function, pain, and fatigue. It aggregates results from databases including Medline, Embase, and Cochrane Library.

Use Cases

• Analyze the standardized mean difference (SMD) and 95% confidence intervals (CIs) for cardiopulmonary function to quantify exercise intervention efficacy.
• Compare effect sizes for mental health versus pain outcomes to identify which symptoms are most responsive to physical activity.
• Examine results from the Cochrane Collaboration Risk of Bias Tool 2.0 assessments to evaluate the methodological quality of included trials.
• Review subgroup and regression analysis findings to explore potential sources of heterogeneity among the six studies.

Strengths

• Aggregates data from 277 participants across six distinct randomized controlled trials.
• Reports precise effect sizes as standardized mean differences with 95% confidence intervals for nine specific health outcomes.
• Employs established methodological tools including the Cochrane Risk of Bias Tool and GRADEpro for evidence certainty.

Limitations

• Limited scope with only 277 total participants, restricting statistical power and generalizability.
• No significant improvements found for key patient-reported outcomes like pain, fatigue, and social aspects.
• The underlying individual participant data is not available, only the aggregated meta-analysis results.

Provenance

Source

Systematic review and meta-analysis conducted by author Qianfei Gao, registered with PROSPERO (CRD42024513141).

Collection Method

Data extracted from six randomized controlled trials identified via searches in Medline, Embase, Scopus, Web of Science, Cochrane Library, SPORTDiscus, and ClinicalTrials.gov.

Time Range

Studies included from database inception to November 2025.

Freshness

Literature search includes studies published up to November 2025; document last updated April 2026.