Meta-Analysis of Probiotic Effects on Diabetic Kidney Disease from 11 Randomized Trials

11 randomized controlled trials involving 726 participants were analyzed in this systematic review and meta-analysis. The study, authored by Zhi-Qing Huang and published on figshare in 2026, evaluated the efficacy of probiotic supplementation on renal function, glycemic control, and inflammatory markers in patients with diabetic kidney disease. Results include significant improvements in serum creatinine, estimated glomerular filtration rate, fasting plasma glucose, and high-sensitivity C-reactive protein.

Use Cases

• Train models to predict treatment efficacy based on aggregated clinical trial results mentioned in the description
• Perform secondary analysis on the relationship between inflammatory markers and renal function outcomes described in the meta-analysis
• Benchmark new probiotic interventions against the pooled effect sizes for glycemic and lipid parameters reported in the review

Strengths

• Includes data from 11 randomized controlled trials, a standard for clinical evidence
• Reports specific meta-analysis results with mean differences and confidence intervals for over 10 clinical parameters
• Uses the Cochrane Risk of Bias tool for quality assessment of included studies

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is a 43.9 KB DOCX document, indicating it is a summary report rather than raw trial data

Provenance

Source

Zhi-Qing Huang via figshare

Collection Method

Systematic review and meta-analysis of studies identified from seven databases including PubMed, Embase, and Cochrane Library.

Time Range

Studies published from database inception to July 2025.

Freshness

Last updated 2026-05-20 05:44:17; freshness should be verified