Table 1_Efficacy and safety of anti-CD20 monoclonal antibody therapy for autoimmune nodopa

A 2025 systematic review and meta-analysis by Zijie Tao synthesizes clinical outcomes for autoimmune nodopathy patients treated with anti-CD20 monoclonal antibodies. The analysis includes 29 studies comprising 118 patients, with quantitative pooling performed on 100 patients reporting standardized outcomes. The study reports a pooled clinical response rate of 92.0% and an adverse event rate of 8.5%.

Use Cases

• Benchmarking treatment response rates for autoimmune nodopathy based on the reported 92.0% pooled clinical response rate.
• Analyzing safety profiles of anti-CD20 therapies based on the documented 8.5% adverse event rate and specific event types.
• Comparing subgroup efficacy for different autoantibody types (e.g., anti-NF155, anti-CNTN1) based on the reported subgroup analysis results.
• Informing clinical trial design for rare neuroimmunological conditions based on the synthesis of 29 observational studies.

Strengths

• Quantitative synthesis includes data from 29 studies and 118 patients, providing a consolidated evidence base.
• Reports specific, calculated metrics: a pooled clinical response rate of 92.0% (95% CI, 84.8–95.9%) and an adverse event rate of 8.5%.
• Includes subgroup analysis results, such as response rates for patients with anti-NF155 (95.2%) and anti-CNTN1 (88.9%) autoantibodies.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• The underlying data is observational, and the authors note a lack of randomized controlled trials, which limits causal inference.
• Row count for the primary data tables is unknown, which may limit suitability assessment for direct analysis.

Provenance

Source

figshare, authored by Zijie Tao.

Collection Method

Systematic literature review and meta-analysis using a generalized linear mixed model (GLMM), sourced from PubMed, Web of Science, Cochrane Library, Embase, and ClinicalTrials.gov.

Time Range

Literature search covered from database inception to August 4, 2025.

Freshness

Last updated 2026-03 17 13:07:07; freshness should be verified.

Geography

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