Helicobacter Pylori Antibiotic Regimen Efficacy and Safety Meta-Analysis

A systematic review and meta-analysis of 57 studies with 19,941 participants evaluates the efficacy and safety of antibiotic regimens for Helicobacter pylori eradication. The work, authored by Yinhara Liao and published on figshare in April 2026, synthesizes data from PubMed, Embase, and Web of Science up to October 2025. It provides pooled eradication and adverse event rates across different treatment protocols.

Use Cases

• Compare pooled eradication rates for sequential, quadruple, dual, and triple therapy regimens from the 127 study arms.
• Analyze the relationship between treatment duration (7-day, 10-day, 14-day) and eradication efficacy using the reported subgroup rates.
• Model adverse event incidence (26.1% pooled) by regimen type, such as comparing sequential therapy (54.1%) to dual therapy (15.8%).
• Investigate sources of heterogeneity identified by meta-regression, including publication year, continent, and acid suppressant type.
• Assess the impact of specific antibiotic classes (e.g., nitroimidazoles, macrolides) on both efficacy and safety outcomes.

Strengths

• Analysis synthesizes data from 57 studies encompassing 19,941 participants across 127 treatment arms.
• Reports specific pooled efficacy (83.0%) and safety (26.1% adverse events) metrics with confidence intervals and heterogeneity measures (I²=87.3%, 95.3%).
• Includes subgroup analyses on multiple factors: regimen type, duration, antibiotic classes, and acid suppressants.

Limitations

• The dataset is a single 209.9 KB document summarizing results, not the underlying patient-level or study-level data, limiting secondary analysis.
• High statistical heterogeneity (I² > 87%) and noted publication bias indicate significant variability between the included studies.
• Temporal coverage is unclear as the search went to 'October 2025', but the specific publication dates of the 57 source studies are not provided.

Provenance

Source

Systematic review of studies from PubMed, Embase, and Web of Science, registered as PROSPERO CRD420251207695.

Collection Method

Meta-analysis following systematic review protocols; pooled estimates calculated using random-effects models with subgroup analyses and meta-regression.

Time Range

Literature searched from database inception to October 2025.

Freshness

Last updated on the platform in April 2026, with literature search current through October 2025.

Geography

Global scope, with studies from multiple continents identified as a source of heterogeneity.