Umbrella Review of Curcumin Formulations for Osteoarthritis Efficacy and Safety

An umbrella review synthesizing evidence from systematic reviews and meta-analyses up to September 2025. It includes 10 meta-analyses and systematic reviews on the efficacy and safety of diverse curcumin formulations for osteoarthritis, authored by Chuankai Shi. The document was last updated on 2026-05-21.

Use Cases

• Compare efficacy signals of curcumin versus NSAIDs based on pain (VAS) and function (WOMAC) outcomes mentioned in the review
• Assess methodological quality of existing systematic reviews based on the AMSTAR-2 assessments described
• Identify research gaps for future comparative trials based on the noted heterogeneity and lack of head-to-head studies
• Inform formulation development strategies based on the discussion of bioavailability-enhancing methods

Strengths

• Includes 10 meta-analyses and systematic reviews, providing a synthesis of existing evidence
• Methodological quality was assessed using the AMSTAR-2 tool, with three studies rated as high quality
• Registered with PROSPERO (CRD420251172722), indicating a structured review protocol

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Findings were synthesized qualitatively due to substantial heterogeneity, limiting quantitative conclusions

Provenance

Source

figshare

Collection Method

Systematic search across PubMed, Web of Science, Cochrane, Embase, Scopus, and MEDLINE

Time Range

Reviews included up to September 2025

Freshness

Last updated 2026-05-21 04:37:08; freshness should be verified