Efficacy and Safety of HIFU vs. Cryoablation for Breast Fibroadenomas

A systematic review and meta-analysis published in 2026, aggregating results from 17 prospective single-arm studies. The analysis compares tumor volume reduction and adverse event rates for high-intensity focused ultrasound and cryoablation treatments for breast fibroadenomas. It was authored by YuanFeng Zhao and shared under a CC-BY-4.0 license.

Use Cases

• Compare treatment efficacy based on pooled tumor volume reduction rates at 6 and 12 months.
• Assess treatment safety profiles based on pooled adverse event rates for HIFU and cryoablation.
• Identify research gaps for future comparative studies based on the limitations of non-randomized single-arm studies.
• Inform clinical decision-making for minimally invasive fibroadenoma treatments based on meta-analytic findings.

Strengths

• Includes 17 prospective studies with sample sizes greater than 10.
• Reports specific pooled outcome rates: 54.4% volume reduction for HIFU at 6 months, 70.3% at 12 months, and adverse event rates of 23% (HIFU) and 7% (cryoablation).
• Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS).

Limitations

• The dataset is a 10.6 KB document; the underlying structured data (rows, columns) is not provided.
• Conclusions are limited by the predominance of non-randomized single-arm studies and substantial data heterogeneity (I² up to 95.6%).
• Quantitative pooling for cryoablation was not feasible due to incomplete statistical reporting in source studies.

Provenance

Source

figshare

Collection Method

Systematic search in PubMed, Embase, and Web of Science up to October 2025, followed by meta-analysis.

Time Range

Studies included up to October 2025.

Freshness

Last updated 2026-05-01 04:18:52.