Meta-Analysis of Lung-Protective Ventilation Efficacy in Neurosurgery, 2000–2025

Yan Liu's meta-analysis synthesizes results from 7 randomized controlled trials involving 523 patients, published on figshare in 2026. The study compares lung-protective ventilation to conventional ventilation for craniotomy patients, analyzing outcomes like postoperative pulmonary complications and intracranial pressure. The analysis was performed using Review Manager 5.2.

Use Cases

• Evaluating the efficacy of lung-protective ventilation based on pooled odds ratios for postoperative pulmonary complications.
• Assessing the safety of ventilation protocols based on surrogate measures for intracranial pressure.
• Analyzing the impact on specific pulmonary outcomes like infection and atelectasis based on reported secondary outcomes.
• Informing clinical trial design based on the identified need for standardized measures and large-scale RCTs.

Strengths

• Includes data from 7 randomized controlled trials, a systematic review methodology.
• Reports specific statistical results, such as an OR of 0.30 for reducing PPCs.
• Clear temporal coverage of literature from 2000 to 2025.
• Released under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 29.0 KB DOC document; the underlying tabular meta-analysis data is not provided as a structured file.
• Column-level documentation is absent; field semantics must be inferred from the document text.
• Conclusions on intracranial pressure are based on surrogate measures (ONSD), as noted in the document.

Provenance

Source

Yan Liu via figshare.

Collection Method

Systematic review and meta-analysis of RCTs from PubMed, Embase, Cochrane Library, and WANFANG databases.

Time Range

Literature search covers 2000–2025.

Freshness

Last updated 2026-04-23 05:35:56; freshness should be verified.