Efficacy and Safety of Neoadjuvant Therapies for Prostate Cancer in Older Adults

15 studies published between 2010 and 2025 were analyzed in this systematic review and network meta-analysis. The research compares the efficacy and safety of neoadjuvant treatments for high-risk and locally advanced prostate cancer in older adults. It was authored by Wenling Yuan and shared on figshare in May 2026.

Use Cases

• Compare treatment efficacy for positive surgical margin rates based on the described pathological outcomes.
• Rank neoadjuvant therapies by safety profile based on the analysis of adverse events.
• Inform clinical trial design for long-term survival studies based on the identified efficacy-toxicity trade-off.
• Analyze treatment impact on minimal residual disease and clinical downstaging based on the secondary outcomes described.

Strengths

• Analysis is based on 15 studies identified through a systematic search of major databases.
• The study uses a Bayesian network meta-analysis framework and SUCRA values for treatment ranking.
• The dataset is shared under a permissive CC-BY-4.0 license.

Limitations

• The primary data file is a 671.9 KB DOCX document, which is a small text file rather than a structured dataset.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of randomized controlled trials and prospective comparative studies.

Time Range

Studies published from January 2010 to April 20, 2025.

Freshness

Last updated 2026-05-21 04:31:25; freshness should be verified.