QUIET Trial: Efficacy and Safety of Qingre Huatan Formula for Acute Ischemic Stroke

A 2025-2026 randomized controlled pilot study by Xiangyi Zheng investigating the efficacy and safety of Qingre Huatan Formula (QHF) for preventing early neurological deterioration in acute ischemic stroke patients. The trial involved 72 patients treated within 48 hours of symptom onset, with outcomes tracked up to 90 days. The dataset likely contains patient-level data on NIHSS scores, modified Rankin Scale scores, and treatment assignments.

Use Cases

• Analyzing the relationship between QHF treatment and NIHSS score changes based on the primary and secondary outcomes.
• Modeling the probability of early neurological deterioration within 7 days based on treatment group and baseline characteristics.
• Assessing functional recovery outcomes (modified Rankin Scale ≤ 2) at 90-day follow-up based on the trial design.
• Comparing efficacy and safety profiles of a traditional Chinese medicine formula against a placebo in a controlled clinical setting.

Strengths

• Data originates from a randomized, double-blind, placebo-controlled clinical trial, a gold-standard study design.
• The trial protocol is clearly defined with a primary outcome (END within 7 days) and secondary outcomes (NIHSS change, functional outcome).
• Includes a 90-day follow-up period, providing medium-term outcome data.
• Published under a CC-BY-4.0 license, allowing for open reuse and redistribution.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (148.3 KB), indicating a limited scope, likely focused on the trial protocol and summary results rather than extensive raw patient data.

Provenance

Source

Xiangyi Zheng, published on figshare.

Collection Method

Data collected as part of the QUIET randomized controlled pilot study (NCT06857487).

Time Range

Trial registered in 2025, with data last updated in 2026.

Freshness

Last updated 2026-04-13 04:35:37; freshness should be verified.

Geography

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