Efficacy and Safety of Vitamin D for Asthma: An Umbrella Review

21 systematic reviews and meta-analyses evaluating vitamin D supplementation for asthma were included in this umbrella review. The document, authored by Yongxiu Liu and published on figshare in May 2026, synthesizes evidence on outcomes like exacerbations, asthma control, lung function, and adverse events. The certainty of evidence for many findings was rated as low or very low.

Use Cases

• Evaluating the association between vitamin D supplementation and asthma exacerbation risk based on the review's primary outcome.
• Assessing the consistency of evidence for asthma control and lung function outcomes based on the description of limited or inconsistent effects.
• Analyzing the safety profile of vitamin D as an adjunctive treatment based on the reported observation of no significant increase in adverse events.
• Identifying gaps for future research on optimal dosing and patient selection based on the conclusions regarding heterogeneity and evidence uncertainty.

Strengths

• Includes 21 systematic reviews and meta-analyses, providing a broad synthesis of existing evidence.
• Applies standard appraisal tools for methodological quality, risk of bias, reporting quality, and certainty of evidence.
• The document is licensed under CC-BY-4.0, allowing for open reuse.

Limitations

• The underlying data format is a DOCX file (815.2 KB), which is not a structured data format suitable for direct analysis.
• Column-level documentation and sample data are unavailable, making field semantics and structure unknown.
• The description notes substantial overlap among primary studies and heterogeneity, which may affect the independence of the synthesized evidence.

Provenance

Source

figshare

Collection Method

Systematic search of PubMed, Cochrane Library, Web of Science, Embase, CNKI, WANFANG, VIP, and CBM from inception to November 26, 2025.

Time Range

Reviews included from database inception to November 2025.

Freshness

Last updated 2026-05-26 05:26:21; freshness should be verified.