Meta-Analysis of Liposomal Bupivacaine Efficacy in Postoperative TAP Blocks

A systematic review and meta-analysis of 13 randomized controlled trials (n=1,528) published from 2000 to 2025, evaluating liposomal versus standard bupivacaine. The analysis, registered in PROSPERO, was authored by Qian Cao and uploaded to figshare in 2026. It reports on outcomes including opioid consumption, pain scores, and recovery times following transversus abdominis plane blocks.

Use Cases

• Comparing analgesic efficacy between liposomal and standard bupivacaine based on reported mean differences in morphine milligram equivalents.
• Evaluating the duration of analgesia and recovery metrics based on reported time to first rescue analgesia and flatus passage.
• Assessing the quality of evidence for pain relief interventions based on the reported low to very low evidence ratings.

Strengths

• Includes data from 13 randomized controlled trials with a total of 1,528 patients.
• Reports specific quantitative outcomes, such as a mean difference of -0.62 mg in opioid consumption and pain score reductions on postoperative days 1-3.
• Follows a registered protocol (PROSPERO CRD420251084761) and includes a defined set of primary and secondary outcomes.

Limitations

• The underlying data tables and column definitions are not provided in the description.
• The quality of evidence for the reported outcomes is rated as low to very low.
• The dataset is a 15.6 KB document, suggesting it contains summary results rather than raw trial data.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of RCTs from PubMed, Cochrane Library, Embase, and Wanfang databases.

Time Range

2000 to 2025

Freshness

Last updated 2026-05-19 11:49:11