Electroacupuncture Effects on Myocardial Ischemia via Exosomal miR-22-3p

Jian Xiong published a research document on figshare in June 2026 under a CC-BY-4.0 license. The document describes a study investigating how electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting NLRP3 inflammasome-mediated pyroptosis via serum exosomal miR-22-3p. The study used animal models and patient serum samples, with findings validated through Western blotting, RT-qPCR, and small RNA sequencing.

Use Cases

• Analyze the molecular mechanism of electroacupuncture therapy based on the described NLRP3 inflammasome pathway.
• Study the role of serum exosomes in remote therapeutic effects based on the described miRNA transport.
• Investigate miR-22-3p as a therapeutic target for myocardial ischemia-reperfusion injury based on the validation experiments described.
• Compare cardiac function and infarction area outcomes between treatment and control groups based on the described echocardiography and staining methods.

Strengths

• The study description includes multiple validation methods such as Western blotting, RT-qPCR, and small RNA sequencing.
• Research involved both in vivo animal models and in vitro cell experiments, as described.
• The document is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a 43.1 KB DOCX file containing a research document, not structured data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Jian Xiong via figshare.

Collection Method

Research study involving animal models of myocardial ischemia-reperfusion injury and serum samples from AMI-PCI patients.

Freshness

Last updated 2026-06-01 09:12:49; freshness should be verified.