Sepsis Patient Cohort Analysis of Vitamin B12 Levels and Mortality Risk

37,660 patients from a retrospective cohort study were analyzed to examine the association between pre-sepsis vitamin B12 levels and clinical outcomes. The data, sourced from the TriNetX database, covers adults diagnosed with sepsis between 2010 and 2024. Elevated vitamin B12 levels (≥1,000 pg./mL) were associated with increased 90-day mortality (26.3% vs. 21.8%) and progression to severe sepsis.

Use Cases

• Predicting 90-day mortality risk in sepsis patients based on pre-existing vitamin B12 levels.
• Analyzing dose-response relationships between vitamin B12 levels (>1,200 pg./mL) and adverse outcomes.
• Investigating differential risk associations in younger patient subgroups (18–65 years).
• Studying secondary outcomes like ICU admission and organ failure linked to biomarker levels.

Strengths

• Includes 37,660 patients after propensity score matching, providing a substantial cohort.
• Analyzes multiple clinical outcomes: 90-day mortality, severe sepsis progression, organ failure, and ICU admission.
• Specifies a clear temporal coverage (2010–2024) and data source (TriNetX database).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect temporal and source bias inherent to the TriNetX database.

Provenance

Source

TriNetX database

Collection Method

Retrospective cohort analysis using 1:1 propensity score matching.

Time Range

2010–2024

Freshness

Last updated 2026-04-24 04:23:41; freshness should be verified.