Multi-Omics Data on Daifu Decoction in Ulcerative Colitis Mouse Model

A 12.6 KB document presents multi-omics data from a study investigating the molecular mechanisms of Daifu decoction in treating ulcerative colitis. The research used a mouse model, 16S rRNA sequencing, transcriptomics, and metabolomics to analyze gut microbiota, gene expression, and metabolic changes. It was authored by Yangyang Zhao and published under a CC BY 4.0 license.

Use Cases

• Analyze 16S rRNA sequencing data to compare gut microbiota diversity and the proportion of beneficial bacterial between treatment and control groups.
• Integrate transcriptomics data to identify key targets like PRKCG and investigate its role in the PKCγ/ERK/NF-κB signaling pathway.
• Correlate metabolomics profiles with clinical outcomes such as proinflammatory factor levels and tight junction protein expression from ELISA and qPCR data.
• Use molecular docking and dynamics simulation results to validate the binding of active DFD components to the PRKCG protein target.

Strengths

• Data integrates multiple analytical techniques: transcriptomics, metabolomics, 16S rRNA sequencing, and experimental verification.
• Study design includes three distinct DFD treatment concentrations (1.6, 3.2, 6.4 g/(kg·d)) for dose-response analysis.
• Findings are supported by molecular docking and molecular dynamics simulations confirming target binding.

Limitations

• The dataset is very small (12.6 KB), suggesting it contains summary-level results rather than raw, high-volume omics data tables.
• Data is derived solely from a mouse model, limiting direct applicability to human ulcerative colitis without further translational research.
• Specific sample sizes, row counts, and column definitions for the underlying data tables are not provided in the description.

Provenance

Source

Yangyang Zhao, via figshare.

Collection Method

Generated from a laboratory study using a DSS-induced ulcerative colitis mouse model treated with Daifu decoction, analyzed via multi-omics and experimental techniques.

Freshness

Last updated on 2026-03-24.