Murine Shock/Sepsis Lung Injury Data on PD-L1 Knockout Impact

Elizabeth W. Tindal's 2026 study provides experimental data on the role of programmed cell death receptor-ligand 1 (PD-L1) in shock/sepsis-induced lung injury. The dataset likely contains results from Cre-lox mouse models, including survival rates, lung permeability measurements, and cytokine/chemokine levels from blood, bronchoalveolar lavage fluid, and lung tissue. Findings indicate a morbid impact from endothelial cell PD-L1 loss but a potential protective role from neutrophil PD-L1 expression.

Use Cases

• Modeling survival outcomes based on cell-specific PD-L1 knockout status.
• Analyzing correlations between lung vascular permeability and cytokine concentrations.
• Comparing biomarker profiles (MCP-1, MIP-2, IL-6, Angiopoietin 2) across different genetic mouse models.

Strengths

• Data is derived from controlled Cre-lox mouse models allowing cell-specific genetic analysis.
• Includes multiple biological sample types: peripheral blood, bronchoalveolar lavage fluid, and lung tissue.
• Measures a range of outcomes: 14-day mortality, lung permeability, and specific cytokine/chemokine levels.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 96.6 KB file size suggests a limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Experimental data from laboratory studies using hemorrhagic shock and cecal ligation and puncture (CLP) models on genetically modified mice.

Freshness

Last updated 2026-06-02 04:28:45; freshness should be verified.