Ellen Caroline Nobre Santos published experimental data on Oropouche virus virulence on figshare in May 2026. The dataset likely contains measurements from a study comparing historical and contemporary reassortant virus strains. It provides evidence for increased pathogenicity in the AG129 mouse model.
Use Cases
- Compare viral virulence metrics between historical and contemporary strains based on the described experimental comparison.
- Analyze viral load distribution across organs based on the mention of spleen, kidney, liver, lung, uterus, testes, and brain.
- Study the relationship between viral evolution and clinical severity based on the biological framework described.
- Investigate pro-inflammatory responses in infection based on the mention of IL-1β upregulation across tissues.
Strengths
- Data is derived from a controlled experimental study comparing specific virus isolates (OROV_SC2024, OROV_AC2024, OROV_BeAn19991).
- The dataset likely includes multi-organ viral load measurements, as described.
- The work provides experimental evidence linking viral evolution to increased pathogenicity, a key finding.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is very small (688.0 B), indicating limited scope.
Provenance
- Source
- Ellen Caroline Nobre Santos
- Collection Method
- Experimental data from a mouse model study.
- Freshness
- Last updated 2026-05-19 05:41:51; freshness should be verified.
- Geography
- Includes isolates from non-Amazonian regions and the Amazon Basin.