Piglet Intestinal Response to ETEC Infection: Necroptosis and Pyroptosis Data

A 16.7 KB dataset from figshare, authored by Xiaoyu Wu and last updated on 2026-03-19, documents the molecular and cellular response of piglets to Enterotoxigenic Escherichia coli infection. The data likely contains measurements of protein levels and inflammatory markers related to necroptosis and pyroptosis in intestinal tissues. It is shared under a CC-BY-4.0 license.

Use Cases

• Modeling the temporal sequence of necroptosis and pyroptosis based on time-dependent protein upregulation mentioned in the description
• Analyzing correlations between epithelial cell death and lymphocyte pyroptosis based on the described causal relationship
• Investigating the impact of Nec-1 pretreatment on inflammation and barrier integrity based on the described mitigation effects

Strengths

• Data is focused on a specific, mechanistic biological pathway (necroptosis/pyroptosis) in a controlled infection model.
• The description details specific measured proteins (p-RIP3, HMGB1, NLRP3, Caspase-1, GSDMD-N, Cleaved-IL-1β) and markers (TNF-α, IL-1β, i-FABP, ZO-1, Occludin).
• Dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (16.7 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely originates from a controlled laboratory study of ETEC infection in piglets, as described.

Freshness

Last updated 2026-03-19 05:20:07; freshness should be verified.