Systematic Review and Meta-Analysis on Endocrine Disruptors and Endometrial Cancer Risk

Lutian Gong published a systematic review and meta-analysis on 2026-05-28, evaluating the association between environmental endocrine-disrupting chemicals and endometrial cancer risk. The work includes quantitative meta-analyses for cadmium and polychlorinated biphenyls (PCBs) and a narrative review of evidence for PFAS, phthalates, and bisphenols. It synthesizes findings from 14 studies published up to November 30, 2025.

Use Cases

• Conducting a meta-analysis on cadmium exposure and cancer risk based on the reported relative risk (RR) and confidence intervals.
• Reviewing the state of evidence for emerging endocrine disruptors like PFAS and bisphenols as described in the narrative synthesis.
• Assessing study heterogeneity and subgroup effects in environmental health research based on the reported I² statistics and subgroup analyses.

Strengths

• Includes a quantitative meta-analysis with specific results, such as a reported RR of 1.22 for cadmium and endometrial cancer risk.
• Applies a systematic review methodology, searching multiple databases (PubMed, Web of Science, EMBASE, Cochrane Library) up to a specified date (November 30, 2025).
• Reports statistical details including confidence intervals and heterogeneity metrics (e.g., I²=72.17% for cadmium).

Limitations

• The dataset is a 45.0 KB document file; the underlying tabular meta-analysis data or individual study data are not provided.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

Lutian Gong via figshare

Collection Method

Systematic literature review and meta-analysis conducted using Stata 18.0.

Time Range

Studies published up to November 30, 2025.

Freshness

Last updated 2026-05-28 04:51:56; freshness should be verified.