Neuroprotective Effects of Hericium Erinaceus Extract in APP/PS1 Mice

2.57 mg/g of ergothioneine was measured in the water extract of Hericium erinaceus HE-17. The dataset likely contains results from a 90-day study on APP/PS1 transgenic mice, assessing cognitive function, inflammation, oxidative stress, and gut microbiota. It was authored by Ping-Ping Gao and uploaded to figshare in May 2026.

Use Cases

• Analyze the relationship between ergothioneine dosage and cognitive improvement based on Morris Water Maze test results.
• Investigate correlations between gut microbiota composition changes (e.g., Lactobacillus abundance) and inflammatory markers.
• Model the dose-response effects of fungal extracts on Aβ aggregation and tau phosphorylation levels.

Strengths

• Includes specific quantitative results, such as extract containing 2.57 ± 0.14 mg/g EGT and doses of 2 g/kg and 0.50 g/kg BW/d.
• Covers multiple assessment modalities: behavioral tests, histopathology, immunofluorescence, biochemical assays, ELISA, and 16S rRNA sequencing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 1.9 MB file size suggests the dataset is relatively small.

Provenance

Source

Ping-Ping Gao via figshare.

Collection Method

Data likely generated from a laboratory study screening 29 Hericium erinaceus isolates and testing extracts in a transgenic mouse model.

Freshness

Last updated 2026-05-21 04:36:23; freshness should be verified.