E. coli Urinary Tract Infection Model in Göttingen Minipigs

Joyce Lübbers established a novel intraurethral infection model using UPEC strain UTI89 in Göttingen minipigs. The model maintained infection for 14 days and strain identity verification revealed 75% of animals retained the challenge strain. This dataset, uploaded on figshare in 2026, aims to bridge preclinical findings and clinical outcomes for vaccine and antibiotic studies.

Use Cases

• Evaluate vaccine efficacy against uropathogenic E. coli based on the described intraurethral challenge model
• Assess antibiotic treatment effectiveness in urinary tract infections based on bacterial enumeration outcomes
• Study strain persistence and identity verification in animal models based on agglutination and whole genome sequencing results
• Bridge preclinical findings to human clinical outcomes based on the minipig model methodology

Strengths

• Model established infection for a 14-day period
• Strain identity was verified using agglutination and whole genome sequencing
• Dataset is openly licensed under CC-BY-4.0

Limitations

• Dataset size is 22.6 KB, indicating limited scope
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Intraurethral challenge with UPEC strain UTI89 using Foley balloon catheters, followed by bacterial enumeration and strain characterization from urine.

Freshness

Last updated 2026-05-18 05:45:01