Estrogen Signaling in Fibroblasts: A Scoping Review of 67 Studies

67 eligible studies were systematically reviewed to map evidence on estrogen signaling in fibroblasts. The review, authored by Neena Roy and published on figshare in March 2026, reveals fibroblast responses to estradiol, phytoestrogens, and SERMs via ERα, ERβ, and GPER receptors. Findings highlight anti-fibrosis, wound healing, and cancer-promoting effects, while noting gaps in sample sizes and mechanistic detail.

Use Cases

• Identify therapeutic targets for estrogen-related disorders based on the review's findings on anti-fibrosis and wound healing effects.
• Analyze receptor-specific pathways in fibroblast signaling based on the discussion of ERα, ERβ, and GPER.
• Model the role of the tumor microenvironment in cancer progression based on the review's findings on cancer-associated fibroblasts.
• Assess the impact of phytoestrogens and SERMs on cell responses based on the reviewed evidence.
• Investigate sex-specific differences in fibroblast biology based on the identified research gaps.

Strengths

• The review systematically analyzed 67 studies from PubMed, Scopus, and EMBASE.
• It covers multiple ligands (estradiol, phytoestrogens, SERMs) and receptors (ERα, ERβ, GPER).
• The work is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a 674 KB DOCX file, indicating a limited scope primarily as a review document.
• Row count and column-level documentation are absent; the content is textual analysis.
• The review itself notes significant gaps in the underlying studies, including small sample sizes and lack of mechanistic detail.

Provenance

Source

Neena Roy via figshare

Collection Method

Systematic search across PubMed, Scopus, and EMBASE, followed by screening in Covidence.

Freshness

Last updated 2026-03-19 08:22:53