Common Carp Cathepsin L Gene Expression and Immune Profiling

Nine cathepsin L paralogs in common carp show tissue-specific expression patterns, with ctsl.1A/B enriched at mucosal barriers and ctslaA/B predominant in systemic immune hubs. The dataset, authored by Sagar Nayak, documents expression profiles across tissues and immune compartments during infection with the myxozoan pathogen Sphaerospora molnari. It was last updated in April 2026.

Use Cases

• Analyze tissue-specific expression partitioning of ctsl.1A/B and ctslaA/B paralogs across mucosal barriers and systemic immune hubs.
• Model structural variation in protease loop architecture and active-site cleft geometry to predict divergent substrate preferences.
• Track temporal reprogramming of ctsl expression profiles in blood and head kidney leukocytes during Sphaerospora molnari infection.
• Correlate ctsl paralog expression dynamics with inflammatory cytokine induction patterns to study uncoupled regulatory networks.

Strengths

• Identifies nine distinct cathepsin L paralogs retained from whole-genome duplication events.
• Provides expression data partitioned across multiple tissues and immune compartments.
• Includes structural modeling predictions for protease architecture variation.
• Documents temporal expression dynamics during a defined pathogen infection.

Limitations

• Dataset size is 3.5 MB, indicating a limited scope or sample count.
• Specific row counts and quantitative expression values are not provided in the description.
• Analysis is confined to a single fish species (common carp), limiting cross-species comparisons.

Provenance

Source

figshare, authored by Sagar Nayak.

Collection Method

Gene identification, expression profiling, and structural modeling from the common carp model.

Time Range

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Freshness

Last updated in April 2026.

Geography

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