Influenza A(H1N1) Hemagglutinin Mutations and Co-Detection Records (2000–2025)

An evidence-mapping synthesis integrates bibliometric analysis and expert curation of 11,848 unique publications on Influenza A(H1N1). It characterizes mutational patterns in hemagglutinin sequences and literature-derived co-detection records with other pathogens. The dataset was authored by Xinrui Cao and published on figshare in March 2026.

Use Cases

• Analyze the post-2010 shift in the HA mutational landscape, focusing on recurrent substitutions at sites S13, S146, S160, and S202.
• Map literature-derived co-detection records to identify frequently reported co-pathogens like RSV and SARS-CoV-2.
• Investigate the conformationally flexible HA segment spanning residues aa190–aa226 for its relevance to the receptor-binding microenvironment.
• Examine the China-focused module's prioritized mutation G219A in Eurasian avian-like H1N1 strains as a hypothesis-generating site.

Strengths

• Integrates 11,848 unique publications from PubMed, Web of Science, and Scopus after deduplication.
• Covers a 25-year temporal range from 2000 to 2025 for longitudinal analysis.
• Includes expert-guided curation and structure-informed interpretation of HA sequences.

Limitations

• The dataset is a 279.0 KB DOC file, indicating a summary document rather than a large, raw data repository.
• Literature-derived co-detection proportions reflect heterogeneous study reporting rather than population-level prevalence.
• Specific row counts and column structures for underlying sequence or co-detection data are not provided.

Provenance

Source

figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis of multiple databases, expert-guided curation, and sequence/structure-informed interpretation.

Time Range

2000–2025

Freshness

Last updated March 2026, providing recent analysis.

Geography

Global scope with a specific China-focused module.