Meta-Analysis of Exosome Therapy Efficacy in Preclinical Epilepsy Models

A systematic review and meta-analysis quantitatively assesses the efficacy of exosome therapy for epilepsy based on eight preclinical animal studies. Yongna Yang authored this document, which was last updated on May 15, 2026. The analysis synthesizes outcomes on seizure reduction, cognitive function, and neuroinflammatory markers.

Use Cases

• Evaluating the therapeutic potential of exosomes based on seizure duration and frequency metrics.
• Assessing cognitive function preservation based on Morris water maze performance outcomes.
• Analyzing neuroinflammatory response based on levels of GFAP, IBA-1, TNF-α, and IL-1β biomarkers.
• Investigating the influence of exosome source, administration route, and dosage on treatment efficacy.

Strengths

• Quantitative meta-analysis includes eight preclinical studies with standardized mean differences and confidence intervals.
• Examines multiple outcome domains: seizure phenotypes, cognitive function, and neuropathological markers.
• Results show statistically significant effects on primary outcomes, such as reducing seizure duration (SMD = -2.30).

Limitations

• The dataset is a 25.3 KB DOCX document; its small size suggests it contains summary text and analysis rather than raw experimental data.
• Row count and column-level documentation are absent; data structure must be inferred from the textual description.
• The analysis is based on a limited pool of eight studies, which may affect generalizability.

Provenance

Source

figshare

Collection Method

Systematic search across four English-language and four Chinese databases for preclinical epilepsy animal studies.

Freshness

Last updated 2026-05-15 05:42:47