Shared Hub Genes and Immune Mechanisms in Latent and Active Tuberculosis

A 2026 study by Xingzhen Yang identified 180 common genes and four hub genes (C1QB, MSR1, OLIG3, TGFB1I1) shared by latent and active tuberculosis infection. The research includes a nomogram risk prediction model and gene set variation analysis to explore coordinated immune activation patterns. The dataset is available under a CC-BY-4.0 license on figshare.

Use Cases

• Training diagnostic classifiers based on the identified four hub genes (C1QB, MSR1, OLIG3, TGFB1I1).
• Analyzing shared immune activation pathways between latent and active TB using Gene Set Variation Analysis (GSVA) results.
• Evaluating clinical prediction models using the described nomogram and its associated ROC and decision curve analyses.
• Investigating the role of Gamma delta T cells and Type 17 T helper cells in tuberculosis immune response.

Strengths

• Identifies 180 common differentially expressed genes shared by latent and active tuberculosis.
• Specifies four hub genes (C1QB, MSR1, OLIG3, TGFB1I1) validated through PPI network and LASSO regression analysis.
• Includes a clinical prediction model (nomogram) evaluated with ROC and decision curve analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 4.1 MB file size suggests a relatively small dataset, potentially limiting scope.

Provenance

Source

figshare, author Xingzhen Yang.

Collection Method

Bioinformatics analysis of gene expression data, including differential expression, PPI network construction, and LASSO regression.

Freshness

Last updated 2026-05-20 10:42:44; freshness should be verified.