Table 1_Exploratory transcriptomic analysis suggests candidate genes associated with loss

A transcriptomic dataset from a prospective study of 17 adult Crohn's disease patients, comparing gene expression between ustekinumab responders and non-responders. The dataset, authored by Jiayi Lin and last updated in May 2026, contains results from RNA sequencing analysis identifying 510 differentially expressed genes. It includes candidate genes validated by qPCR in an additional 16 patients.

Use Cases

• Identify candidate biomarkers for ustekinumab treatment failure based on the 510 differentially expressed genes.
• Validate the role of specific pathways like platelet activation and neutrophil extracellular trap formation in drug non-response.
• Assess the potential of genes like FFAR2, ITGA2B, SOCS3, and KCNJ15 as predictors of treatment outcome.
• Explore the association between a 'pro-fibrotic immune microenvironment' and intestinal stricturing behavior in Crohn's disease.

Strengths

• Includes results from RNA sequencing of 17 patients and qPCR validation in an additional 16 patients.
• Identifies 510 differentially expressed genes with defined exploratory thresholds (|FC| > 1.5, P < 0.05).
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (12.9 KB), indicating limited scope, likely containing summary results rather than raw sequencing data.
• Data may reflect geographic bias inherent to the single hospital (Second Affiliated Hospital of Guangzhou Medical University) source.

Provenance

Source

figshare, authored by Jiayi Lin.

Collection Method

Prospective study collecting peripheral blood mononuclear cells from Crohn's disease patients for RNA sequencing and qPCR validation.

Time Range

Patients received initial ustekinumab treatment between January 2024 and June 2025.

Freshness

Last updated 2026-05-21 22:01:35; freshness should be verified.

Geography

Patients were admitted to the Second Affiliated Hospital of Guangzhou Medical University, suggesting a Chinese cohort.