Baicalein Anti-Tumor Mechanisms in Choroidal Melanoma

Integrated analysis data from a 2026 study by Lili Wu investigates the anti-cancer effects of the flavonoid baicalein on choroidal melanoma cells. The dataset combines computational predictions from network pharmacology and transcriptomics with in vitro and in vivo experimental validation results. It is a small supplementary file of 10.4 KB, published under a CC-BY-4.0 license on figshare.

Use Cases

• Identify potential drug targets for baicalein in choroidal melanoma using network pharmacology results.
• Analyze transcriptomic data to explore gene expression changes related to cell cycle and apoptosis pathways.
• Validate computational predictions by examining experimental data on cell proliferation, migration, and protein phosphorylation levels.
• Study pathway dependency by comparing effects of baicalein with and without IGF-1 co-treatment data.

Strengths

• Data integrates three distinct methodologies: network pharmacology, transcriptomics, and wet-lab experiments.
• Includes validation from both cell line models (C918, OCM-1) and an allograft tumor model.
• Published in 2026, representing recent research.

Limitations

• The dataset is very small at 10.4 KB, indicating limited raw data or summary-level results only.
• Specific row counts, column names, and sample-level data are unavailable.
• Findings are specific to choroidal melanoma and two cell lines, limiting generalizability.

Provenance

Source

Lili Wu, published on figshare.

Collection Method

Combined computational analysis (network pharmacology, molecular docking, transcriptomics) with intracellular/extracellular experiments and western blotting.

Time Range

Study period not specified; publication date is 2026.

Freshness

Last updated in April 2026.

Geography

null