Transcriptomic Responses of Vaginal Lactobacilli to Synthetic Hormones

RNA-seq transcriptome profiling data from a study exposing vaginal Lactobacillus species to drospirenone and ethinylestradiol under simulated vaginal conditions. The dataset, authored by Aryanna Muscò and published on figshare in April 2026, likely contains gene expression changes for strains like Lactobacillus crispatus PRL2021.

Use Cases

• Identify hormone-responsive genes in Lactobacillus crispatus based on transcriptomic modulation mentioned in the description
• Analyze pathways for cell wall biosynthesis and metabolism based on upregulated gene categories
• Investigate potential links between riboflavin biosynthesis genes and mucosal protection based on ribBA and ribE upregulation
• Compare species-specific transcriptional responses among vaginal Lactobacillus strains based on the study's methods

Strengths

• Data is derived from RNA-seq transcriptome profiling, a high-resolution molecular technique
• Focuses on specific synthetic hormones (drospirenone and ethinylestradiol) and representative Lactobacillus species
• Published under an open CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is 922.7 KB, indicating a limited scope likely focused on specific experimental results

Provenance

Source

figshare

Collection Method

Generated from laboratory experiments involving growth assays and RNA-seq transcriptome profiling

Freshness

Last updated 2026-04-09 04:10:17; freshness should be verified