GHR Ratio and MASLD Risk in Non-Diabetic Japanese Adults, 2004–2015

A 2004–2015 cross-sectional study of 13,682 non-diabetic Japanese adults from the NAGALA cohort, investigating the fasting blood glucose to HDL cholesterol ratio (GHR) and its association with metabolic dysfunction-associated steatotic liver disease (MASLD). The dataset, authored by Yanyan Xuan and shared under CC-BY-4.0, includes results showing a 15.25% MASLD prevalence and mediation analysis indicating BMI accounts for 59.86% of the GHR-MASLD association.

Use Cases

• Modeling non-linear threshold effects in clinical risk factors based on the identified GHR threshold of 4.62.
• Evaluating biomarker diagnostic performance based on the reported AUC of 0.815 for GHR.
• Conducting mediation analysis to quantify intermediary factors like BMI in metabolic pathways.
• Studying population-specific metabolic health patterns in a non-diabetic Japanese cohort.

Strengths

• Includes results from a large cohort of 13,682 participants.
• Provides specific statistical metrics, including an odds ratio of 1.23 and an AUC of 0.815.
• Clear temporal coverage from 2004 to 2015.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 28.7 KB file size suggests the dataset is likely a summary table or document, not the raw underlying data.

Provenance

Source

NAGALA cohort study.

Collection Method

Cross-sectional study using logistic regression, generalized additive models, and mediation analysis.

Time Range

2004–2015

Freshness

Last updated 2026-04-13 05:30:46; freshness should be verified.

Geography

Japan