Mouse Multi-Omics Data on Fentanyl-Induced Tissue Damage

Multi-omics data from an SKH-1 mouse model investigates fentanyl's effects on cortex, heart, and lung tissues. The dataset captures postmortem tissue samples collected at 40 minutes, 6 hours, 24 hours, and 7 days after administration of three fentanyl doses: HNLD, LD10, and LD50. It was generated by Nabarun Chakraborty to analyze immune response and apoptosis-necrosis networks across time and dose gradients.

Use Cases

• Analyze dose-dependent latency of cortical and pulmonary immune responses across the three fentanyl dose levels.
• Compare the longitudinal trajectory of apoptosis-necrosis activation between heart, lung, and cortex tissues over four time points.
• Identify conserved miRNA biomarkers, such as miR-146-5p and miR-877-3p, showing consistent regulation in specific tissues independent of time and dose.
• Model tissue-specific host response profiles by integrating multi-omics data from the three organ types.

Strengths

• Data integrates multi-omics analysis across three distinct tissue types: cortex, heart, and lung.
• Experimental design includes four post-exposure time points and three defined fentanyl dose gradients.
• Dataset is shared under a permissive CC BY 4.0 license for broad reuse.

Limitations

• The dataset is very small at 71.3 KB, indicating limited scope and likely a summary or processed results rather than raw omics data.
• Sample size and number of biological replicates per condition are unknown, limiting statistical power assessment.
• Data is specific to the SKH-1 mouse strain, which may limit direct translation to other models or human biology.

Provenance

Source

Nabarun Chakraborty via figshare.

Collection Method

Generated from an SKH-1 mouse model; cortex, heart, and lung tissues were collected postmortem for multi-omics analysis.

Time Range

Post-exposure time points: 40 minutes, 6 hours, 24 hours, and 7 days.

Freshness

Last updated March 2026.