Ferroptosis-Pyroptosis Crosstalk Gene Signature for Sepsis-Induced ARDS

10 ferroptosis-pyroptosis crosstalk genes identified as potential prognostic biomarkers for sepsis-induced acute respiratory distress syndrome. Author Lizhou Song published this gene signature analysis on figshare under a CC-BY-4.0 license, last updated in May 2026. The dataset likely contains gene expression data validated by quantitative PCR and ELISA assays.

Use Cases

• Prognostic biomarker discovery based on the 10 identified ferroptosis-pyroptosis crosstalk genes.
• Therapeutic target identification based on key dysregulated genes like GPX4, GSDMD, SLC7A11, and CASP1.
• Pathway enrichment analysis based on inflammatory response, oxidative stress, and cell death pathways.
• Single-cell RNA sequencing validation based on heterogeneous expression patterns across immune cell populations.

Strengths

• 10 specific crosstalk genes are identified, including key genes GPX4, GSDMD, SLC7A11, and CASP1.
• Analysis includes validation via quantitative PCR and ELISA assays.
• Single-cell RNA sequencing provides cell type-specific expression patterns.

Limitations

• The dataset is a 14.7 KB DOCX file, suggesting limited raw data scope.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• Data freshness should be verified as the last update is scheduled for 2026-05-15.

Provenance

Source

figshare

Collection Method

Analysis of gene expression data from sepsis and ARDS patients, single-cell RNA sequencing, and experimental validation.

Freshness

Last updated 2026-05-15 05:42:51