Candida albicans Extracellular Vesicle Effects on Oral Epithelial Immune Responses

Fluconazole-tolerant Candida albicans isolates induced stronger proinflammatory cytokine expression in human oral epithelial cells compared to susceptible isolates. The dataset likely contains experimental results from a study comparing extracellular vesicles from clinical isolates, published by Patcharin Thammasit on figshare in 2026. Findings suggest a link between antifungal tolerance and altered immunomodulatory capacity at the mucosal interface.

Use Cases

• Compare immune activation profiles based on cytokine expression data (IL-1β, IL-6, TNF-α) mentioned in the description
• Investigate the relationship between antifungal tolerance and extracellular vesicle function based on the described experimental framework
• Analyze the effects of fungal extracellular vesicles on epithelial barrier integrity and antimicrobial peptide production (hBD-2, hBD-3)

Strengths

• Results were reproducible across independent biological replicates, as stated in the description.
• The study compared multiple specific immune markers, including proinflammatory cytokines and antimicrobial peptides.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 704.4 KB file size suggests a limited scope of data.

Provenance

Source

figshare

Collection Method

Experimental study comparing extracellular vesicles from fluconazole-tolerant and susceptible Candida albicans clinical isolates on human oral epithelial cells (FaDu).

Freshness

Last updated 2026-04-28 05:28:04; freshness should be verified.